monitoring cyclosporine absorption: a step beyond therapeutic drug monitoring
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منابع مشابه
Monitoring Cyclosporine Absorption: A Step Beyond Therapeutic Drug Monitoring
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In their recent large, retrospective, cross-sectional study with 7702 renal-transplant patients, Einollahi et al. showed that cyclosporine (CsA) absorption (CA) steadily increases over 3 years post transplant (1). They also indicated that despite the day-today and inter-in...
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Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
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Therapeutic monitoring of immunosuppressive therapy with cyclosporine is a critical requirement because of intraand interpatient variability of drug absorption, narrow therapeutic window and drug induced nephrotox icity. The most widely used procedure involves measuring trough concen trations of cyclosporine (CsA) parent drug in whole blood using a specific monoclonal immunoassay. Trough conc...
متن کاملTherapeutic drug monitoring
(Suggestions are based on Level III and IV evidence) • In both adults and children, C2 monitoring of CSA is superior to C0 as a predictor of AUC 0–4 and AUC 0–12. The C3 level is marginally superior to C2 for AUC 0–12. • Targeting AUC 0–4 levels for CSA of greater than 4400 ng/mL or C2 levels of greater than 1.5 by the end of the first week post transplant is associated with less acute rejectio...
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عنوان ژورنال:
nephro-urology monthlyجلد ۵، شماره ۱، صفحات ۷۱۲-۷۱۳
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